It will help a little because you actually focus your RX lobe more towards the “served” MS and less towards the “neighbour” MS.
The C will increase, but the I will decrease.
However the benefits strongly depend on your terrain topography. If flat city, then improvements are high. If hilly open area, improvements will be less.
Another angle to decrease the UL interference is to adjust your UL power control settings to more aggressive thresholds (reduce by -5dB), and faster averaging windows. Try to decrease the power increment steps, so that MS won’t transmit too strong too quickly.
Also, don’t forget to activate UL DTX for EFR and HR calls (it should be done by default).