You’re saying there is no HO towards those neighbors anyway.. if there is no HO, the only load is a “static” load, induced by the size of the neighbor list… This list is handled by OMCR, BSC and BTS. Not MSC (unless you define a lot of adjacencies between cells from different MSC…)
If there is a lot of inter-BSC HO or inter-MSC HO, then you will load your MSC. But only when there are actual HO requests. No request, no load.